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del Peso Santos, Teresa; Alvarez, Laura; Sit, Brandon; Irazoki, Oihane; Blake, Jonathon; Warner, Benjamin R; Warr, Alyson R; Bala, Anju; Benes, Vladimir; Waldor, Matthew K; Fredrick, Kurt; Cava, Felipe BipA exerts temperature-dependent translational control of biofilm-associated colony morphology in textitVibrio cholerae Journal Article In: eLife, vol. 10, pp. e60607, 2021, ISSN: 2050-084X. Abstract | Links | BibTeX | Tags: biofilm, BipA, HapR, temperature, textit{Vibrio cholerae}, translation@article{10.7554/eLife.60607,
title = {BipA exerts temperature-dependent translational control of biofilm-associated colony morphology in textitVibrio cholerae},
author = {Teresa del Peso Santos and Laura Alvarez and Brandon Sit and Oihane Irazoki and Jonathon Blake and Benjamin R Warner and Alyson R Warr and Anju Bala and Vladimir Benes and Matthew K Waldor and Kurt Fredrick and Felipe Cava},
editor = {Wendy S Garrett and Tâm Mignot and Jay Zhu},
url = {https://doi.org/10.7554/eLife.60607},
doi = {10.7554/eLife.60607},
issn = {2050-084X},
year = {2021},
date = {2021-02-01},
journal = {eLife},
volume = {10},
pages = {e60607},
publisher = {eLife Sciences Publications, Ltd},
abstract = {Adaptation to shifting temperatures is crucial for the survival of the bacterial pathogen textitVibrio cholerae. Here, we show that colony rugosity, a biofilm-associated phenotype, is regulated by temperature in textitV. cholerae strains that naturally lack the master biofilm transcriptional regulator HapR. Using transposon-insertion mutagenesis, we found the textitV. cholerae ortholog of BipA, a conserved ribosome-associated GTPase, is critical for this temperature-dependent phenomenon. Proteomic analyses revealed that loss of BipA alters the synthesis of >300 proteins in textitV. cholerae at 22°C, increasing the production of biofilm-related proteins including the key transcriptional activators VpsR and VpsT, as well as proteins important for diverse cellular processes. At low temperatures, BipA protein levels increase and are required for optimal ribosome assembly in textitV. cholerae, suggesting that control of BipA abundance is a mechanism by which bacteria can remodel their proteomes. Our study reveals a remarkable new facet of textitV. cholerae’s complex biofilm regulatory network.},
keywords = {biofilm, BipA, HapR, temperature, textit{Vibrio cholerae}, translation},
pubstate = {published},
tppubtype = {article}
}