Matilda Rentoft

@article{rentoft_coates_loljung_wilms_laurell_nylander_2014,

title = {Expression of CXCL10 is associated with response to radiotherapy and overall survival in squamous cell carcinoma of the tongue},

author = {Matilda Rentoft and Philip John Coates and Lotta Loljung and Torben Wilms and Göran Laurell and Karin Nylander},

doi = {10.1007/s13277-013-1549-6},

year  = {2014},

date = {2014-01-01},

journal = {Tumor Biology},

volume = {35},

number = {5},

pages = {4191–4198},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{rentoft_coates_laurell_nylander_2012,

title = {Transcriptional Profiling of Formalin Fixed Paraffin Embedded Tissue: Pitfalls and Recommendations for Identifying Biologically Relevant Changes},

author = {Matilda Rentoft and Philip John Coates and Göran Laurell and Karin Nylander},

doi = {10.1371/journal.pone.0035276},

year  = {2012},

date = {2012-01-01},

journal = {PLoS ONE},

volume = {7},

number = {4},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Rentoft379848,

title = {miRNA analysis of formalin-fixed squamous cell carcinomas of the tongue is affected by age of the samples},

author = {Matilda Rentoft and Jessica Fahlén and PJ Coates and Göran Laurell and Björn Sjöström and Patrik Rydén and Karin Nylander},

doi = {10.3892/ijo_00000824},

year  = {2011},

date = {2011-01-01},

journal = {International Journal of Oncology},

volume = {38},

number = {1},

pages = {61--69},

publisher = {Spandidos Publ. Ltd},

institution = {Umeå University, Department of Mathematics and Mathematical Statistics},

abstract = {Global miRNA expression arrays were used for analysis of 836 miRNAs in formalin-fixed paraffin-embedded samples from 21 tongue cancer patients and 8 controls. Samples had been stored for one to eleven years. Results separated tumour samples from controls, however, the largest variation was correlated to sample storage time, detectable already after one year. With the use of a linear regression model we could adjust for the storage-dependent effect, leading to the identification of 54 differentially expressed miRNAs in tongue cancer, compared to 16 when using standard normalization, including up-regulation of a novel miRNA, miR-424.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Rentoft402617,

title = {Tubulin-α-6-chain is a stably expressed reference gene in archival samples of normal oral tissue and squamous cell carcinoma of the head and neck},

author = {Matilda Rentoft and Sara Hultin and Philip J Coates and Göran Laurell and Karin Nylander},

doi = {10.3892/etm_00000065},

year  = {2010},

date = {2010-01-01},

journal = {Experimental and Therapeutic Medicine},

volume = {1},

number = {3},

pages = {419--423},

institution = {Umeå University, Otorhinolaryngology},

abstract = {One of the most critical factors in gene expression studies using quantitative real-time PCR is the choice of reference gene. Many of the commonly used reference genes have been shown to vary during a number of biological processes as well as between tissues. It is therefore important to always verify the stability of the gene of choice for all new tissues and experimental conditions. Here, we used two publicly available computer software packages (GeNorm and NormFinder) to investigate the stability of eight potential reference genes in formalin-fixed paraffin-embedded (FFPE) samples from normal oral tissue of different origin as well as from oral squamous cell carcinomas. Both programs found the tubulin α-6 chain (TUBA6) and ribosomal protein S13 (RPS13) to have the most stable expression between malignant and non-malignant tissue. NormFinder also found TUBA6 to be the most stable gene when samples were grouped according to tissue origin. FFPE samples constitute a large research resource, which considerably increases the number of samples available for analysis, leading to more reliable conclusions. Verification of a proper reference gene in oral FFPE tissue is therefore of great importance for future studies.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Rentoft282268,

title = {Gene expression profiling of archival tongue squamous cell carcinomas provides sub-classification based on DNA repair genes},

author = {Matilda Rentoft and Göran Laurell and Philip John Coates and Björn Sjöström and Karin Nylander},

doi = {10.3892/ijo_00000450},

year  = {2009},

date = {2009-01-01},

journal = {International Journal of Oncology},

volume = {35},

number = {6},

pages = {1321--1330},

institution = {Umeå University, Otorhinolaryngology},

abstract = {A subgroup of patients with squamous cell carcinoma of the head and neck (SCCHN) comprise young persons under the age of 40, who have not been heavily exposed to the classical risk factors, smoking and alcohol. The number of SCCHN in young adults, particularly tongue tumours, is increasing in several parts of the world. Here we employed a novel gene expression array methodology specifically developed for analysis of degraded RNA and investigated the expression of 502 cancer-related genes in archival paraffin-embedded SCCHN of the tongue from young (< or =40) and elderly patients (> or =50). Genes detected as de-regulated in tumours compared to non-malignant controls were in concordance with results from earlier studies of fresh frozen material. No genes were detected as significantly differentially expressed between young and old patients suggesting that the overall pathobiology of SCCHN is similar in young and old. Unsupervised clustering divided tumours into three groups, irrespective of age, where several differentially expressed DNA repair genes were a prominent separation factor. High levels of DNA repair genes associated with impaired therapeutic response to radiation, suggesting that DNA repair genes play a role in clinical outcome after radiotherapy.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Rentoft911800,

title = {Enhancer requirement for histone methylation linked with gene activation},

author = {Matilda Rentoft and Kihoon Kim and Youngran Cho and Choon-Hwan Lee and AeRi Kim},

doi = {10.1111/j.1742-4658.2008.06728.x},

year  = {2008},

date = {2008-01-01},

journal = {The FEBS Journal},

volume = {275},

number = {23},

pages = {5994--6001},

institution = {Umeå University, Pathology},

abstract = {Enhancers cause a high level of transcription and activation of chromatin structure at target genes. Hyperacetylation of histones H3 and H4, a mark of active chromatin, is established broadly across target loci by enhancers that function over long distances. In the present study, we studied the role of an enhancer in methylation of various lysine residues on H3 by comparing a model gene locus having an active enhancer with one in which the enhancer has been inactivated within the context of minichromosomes. The intact enhancer affected histone methylation at K4, K9 and K36 in distinct ways depending on the methylation level and the location in the locus. All three lysine residues were highly tri-methylated in the coding region of the gene linked to the active enhancer but not the inactive enhancer. However di-methylation of K9 and K36 was not affected by the enhancer. The enhancer region itself was marked by mono-methylation at K4 and K9, distinguishing it from the methyl marks in the gene coding region. These results indicate that an enhancer has roles in establishing active histone methylation patterns linked with gene transcription rather than removing methylation linked with gene inactivation.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}